胰腺癌发病率有增多趋势,且发现时大部分已是晚期,手术切除率低,化疗效果差,迫切需要一些新的治疗方法。分子生物学和免疫技术的发展为胰腺癌的免疫治疗提供了更新的理论基础和实践工具。本文就胰腺癌免疫治疗的具体策略,包括单克隆抗体治疗、免疫调节剂治疗、过继性免疫治疗及主动性免疫治疗最新研究进展予以综述。 The incidence of pancreatic cancer has an increasing trend, and found that most of them are late, surgical resection rate is low, the effect of chemotherapy is poor, there is an urgent need for some new treatments. The development of molecular biology and immunology provides new theoretical foundation and practical tools for the immunotherapy of pancreatic cancer. This article reviews the specific strategies for immunotherapy of pancreatic cancer, including the recent research progress of monoclonal antibody therapy, immunomodulator therapy, adoptive immunotherapy and active immunotherapy.