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现在已清楚许多激素,包括生长激素、促肾上腺皮质激素、胰岛素、雄激素、甲状腺素、糖皮质激素和盐皮质激素,在增加器官重量、RNA和蛋白质合成、DNA合成和有丝分裂活性以及鸟氨酸脱羧酶活性方面能促进肾生长。除了这些促进肾生长的激素以外,Nicholson等证明,还有一种绵羊垂体分泌的多肽片断能促肾增大,其依据是这一因子能增加经阉割并切除垂体的大鼠肾重量。经生化分析这一多肽片断主要由LH组成,不含生长激素、促肾上腺皮质激素、γ-促脂解激素、加压素和催乳素,而仅含少量的TSH和FSH。每天给切除垂体的大鼠注射生长激素、促肾上腺皮质激素、催乳素、TSH和FSH都不能刺激肾生长。为了解答垂体分泌的促肾素(renotropin)活性是否归因于LH内在活性的疑问,Nicholson等检测了
It is now clear that many hormones, including growth hormone, adrenocorticotropic hormone, insulin, androgens, thyroxine, glucocorticoids and mineralocorticoids, play an important role in increasing organ weights, RNA and protein synthesis, DNA synthesis and mitotic activity, Decarboxylase activity can promote kidney growth. In addition to these hormones that promote kidney growth, Nicholson et al. Demonstrated that there is another piece of polypeptide secreted by the sheep pituitary that promotes renal enlargement based on the fact that this factor increases the renal weight of castrated and excised pituitary rats. The biochemical analysis of this peptide fragment is mainly composed of LH, free of growth hormone, adrenocorticotropic hormone, γ-lipotropin, vasopressin and prolactin, but only a small amount of TSH and FSH. Injections of growth hormone, adrenocorticotropic hormone, prolactin, TSH, and FSH into the excised pituitary were not daily stimulated kidney growth. In order to find out whether the pituitary secretion of renotropin activity is due to the intrinsic LH activity, Nicholson et al.