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目的：探讨内镜与腹腔镜治疗源于固有肌层胃间质瘤的安全性及有效性，对比分析两种治疗方法的优缺点。方法选取2012年1月至2015年5月烟台毓璜顶医院收治的胃固有肌层间质瘤患者55例，将其分为内镜治疗组20例和腹腔镜治疗组35例。内镜治疗组接受内镜黏膜下剥离术（ESD）12例，内镜黏膜下挖除术（ESE）5例，内镜全层切除术（EFR）3例。切除标本行病理组织活检和免疫组化。比较两组的完整切除率、手术时间、住院时间、术后通气通便时间、并发症发生率及复发率等。结果内镜治疗组住院时间为（6.65±2.03）d，短于腹腔镜组的（9.09±2.68）d（P0.05），随访期间两组均无复发病例。结论符合一定条件的胃固有肌层间质瘤可通过内镜完整切除，疗效确切，且创伤小、恢复快，可作为部分外科手术和腹腔镜治疗的补充，值得推广应用。同时两者仍有一定的局限性，双镜联合可能会成为新的治疗趋势。“,”Objective To analyze and compare the safety and feasibility of endoscopy and laparoscopy in resection of gastic stomal tumor originated from the muscularis propria. Methods Of the 55 gastirc stomal tumors originated from the muscularis propria,20 were treated by endoscopic mico-traumatic surgery and 35 by laparoscopic surgery.To evaluate the superiority and infefriority of the two methods by comparing the operating time,complete resection rate,hospitalization time,recovery of bowel function,incidence of coplications,recurrence rate. Results Compared with the laparoscopic group,the endoscopic group required shorter hospitalization time [(6.65±2.03) d vs (9.09±2.68) d,P0.05). Conclusion Gastric stromal tumors originated from the muscularis propria can be completely resected by endoscopy without the assist of laparoscopy if the tumors conform with certain conditions,furthermore the patient recover faster with less-injury.Therefore endoscopy can be regard as a alternative to surgy and laparoscopy to some extent.Meanwhile the two methods still have limitations each other,endoscopy combied laparoscopy is likely to be a new norm in the future.