目的探讨灰质异位症的临床表现及影像学特点。方法回顾性分析4例灰质异位症患者临床表现及CT和MRI资料。结果所有患者均出现癫痫发作,智力下降,影像学可见脑室周围或脑白质内出现灰质影像。1例合并巨脑回畸形、双侧脑室融合畸形。结论结合癫痫发作的病史、神经智力发育障碍、神经系统功能缺失以及影像学表现,可诊断灰质异位症 Objective To investigate the clinical manifestations and imaging features of gray matter disease. Methods The clinical manifestations, CT and MRI data of 4 patients with gray matter disease were retrospectively analyzed. Results All patients had seizures and mental retardation. Cerebral gray matter imaging appeared in the periventricular or white matter of the brain. 1 case with giant brain deformity, bilateral ventricular fusion deformity. Conclusion Combined with the history of seizures, neurological mental retardation, neurological deficits and imaging findings, can be diagnosed with gray matter disease