合霉素乃一九四九年首先由苏联合成的抗菌素,内含左旋和右旋霉素各半。其药理作用与氯霉素相同,但其抗菌效能仅为后者之50％。在临床上主要用于伤寒、菌痢、流感杆菌脑膜炎、布氏杆菌病、立克次体病及尿路感染等。近年来,国内已能用合成法大量生产合霉素,其价格低廉,为临床医界所乐用,故目前渐有取氯霉素而代之之势。有关合霉素临床应用及毒性反应之报告已不少,其副作用方面如:精神症状、骨髓抑制现象、过敏性休克等均有提及。关于合霉素药疹国内外文献中亦已有一些报导(1—10)但大组的病例总结则仍不多。作者最近用国产合霉素治疗沙门氏菌属感染(包括伤寒、副伤寒)中,共发现合霉素 Tetracycline was the first antibiotic synthesized by the Soviet Union in 1949, containing half of levamisole and right-winistomycin. Its pharmacological effects and chloramphenicol same, but its antibacterial efficacy is only 50% of the latter. In clinical mainly for typhoid fever, bacillary dysentery, influenza bacilli meningitis, brucellosis, rickettsial disease and urinary tract infections. In recent years, the country has been able to mass production of Synthetic Synthetic Synthesis, its low price, for the clinical use of the music, it is gradually taking chloramphenicol instead of the potential. There are a lot of reports on the clinical application and toxic reaction of tetracycline. The side effects such as psychosis, myelosuppression and anaphylactic shock are all mentioned. There have also been some reports in the literature about coxicillin drug eruptions (1-10). However, there are still not many cases of large drug group. Recently, the authors used domestic chlortetracycline treatment of Salmonella infections (including typhoid, paratyphoid), were found seicin