目的：考察盐酸３（Ｎ，Ｎ二乙胺）丙基吲哚美辛（ｐｒｏｄｒｕｇ）抗炎及致溃疡作用．方法：观察大鼠角叉菜胶（Ｃａｒ）性炎症反应及口服给药胃溃疡指数的变化．结果：腹腔给药显著抑制Ｃａｒ性趾水肿，３ｈ及５ｈ的抑制率分别为３６５７％和３４５６％，与等摩尔浓度的吲哚美辛（Ｉｎｄ）差异无显著性；足趾１０μｇ／ｐａｗ给药达到６４％的抑制率，再增加剂量不能增加效果；１４１８ｍｇ·ｋｇ－１的ｐｒｏｄｒｕｇ灌胃６小时后溃疡指数显著低于同摩尔数Ｉｎｄ．结论：该药为一抗炎作用强，致溃疡性低的药物． Objective: To investigate the anti-inflammatory and anti-ulcer effects of 3 (N, NDethylamine) propyl indomethacin hydrochloride. Methods: The carrageenan (Carcin) inflammatory reaction and oral administration of gastric ulcer index in rats were observed. RESULTS: Intraperitoneal injection significantly inhibited carinae toe edema. The inhibitory rates at 3h and 5h were 3657% and 3456%, respectively. There was no significant difference between the two groups in indole mesylate (Ind) / Paw administration reached 64% inhibition rate, and then increase the dose can not increase the effect; 14. 18mg · kg-1 prodrug 6 hours after gavage ulcer index was significantly lower than the same number of moles Ind. Conclusion: The drug is a strong anti-inflammatory effect, ulcer caused by low drug.