采用流化床包衣法,分别用苏丽丝和尤特奇为包衣材料,制备了2种释药速率的磷酸卡维地洛缓释微丸。考察了2种微丸在不同混合比例下灌装得到的胶囊在pH 6.8磷酸盐缓冲液(含0.05%Tween-80)中的释放行为,并评价其与原研制剂(Coreg CR)的释放行为相似性。结果表明,在4种介质(pH 1.2盐酸、pH 4.5磷酸盐缓冲液、含0.05%Tween-80的pH 6.8磷酸盐缓冲液和水)中,将2种微丸照各自主成分各占胶囊标示量50%比例混合后灌装得到的自制胶囊与原研制剂释放曲线的相似因子(f_2)大于50。 Two kinds of drug delivery rate carvedilol sustained-release pellets were prepared by using fluidized bed coating method and Sullivs and Eutech as coating materials respectively. The release behaviors of the two kinds of pellets filled with different mixing ratio in pH 6.8 phosphate buffer (containing 0.05% Tween-80) were investigated and the release behaviors of the pellets similar to the original preparation (Coreg CR) were evaluated Sex. The results showed that in the 4 media (pH 1.2 hydrochloric acid, pH 4.5 phosphate buffer, pH 6.8 phosphate buffer with 0.05% Tween-80, and water) The similarity factor (f_2) of the homemade capsule filled with 50% of the total volume of the self-made capsule after filling was greater than 50.