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目的：研究苯吸入染毒对小鼠脂质过氧化物及有关酶活性影响，为寻找早期监测指标提供依据。方法：采用静式吸入染毒法，浓度取１／８ＬＣ５０～１／１２８ＬＣ５０，分为３组，另设不染毒对照组，研究不同浓度、不同时间染苯对脂质过氧化物及有关酶的影响。染毒３０ｄ，每天２ｈ。染毒结束后取血作白细胞计数丙二醛（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨＰｘ）的测定。统计采用Ｆ检验及ｑ检验。结果：血白细胞差异无显著性（Ｐ＞０．０５），且在正常值范围。ＭＤＡ的含量随浓度的增加和时间的延长而增加（Ｐ＜０．０５），且呈剂量反应关系；ＳＯＤ的活性随浓度的增加而增高（Ｐ＜０．０５），但染毒时间延长则无明显变化。ＧＳＨＰｘ的活性随浓度的增加和时间的延长而减少（Ｐ＜０．０５），且呈剂量反应关系。结论：ＭＤＡ、ＳＯＤ、ＧＳＨＰｘ的测定比白细胞计数更早期、敏感的反映苯对机体的毒性作用，对接触苯作业工人的早期监测有一定意义。
OBJECTIVE: To study the effects of benzene inhalation on lipid peroxidation and related enzyme activity in mice and provide basis for searching early monitoring indexes. Methods: The rats were randomly divided into three groups with 1 / 8LC50-1 / 128LC50 concentration by inhalation. The rats in different concentration and time were used to study the effects of benzene on lipid peroxidation and related enzymes Impact. Exposure 30d, 2h daily. Blood samples were taken for the determination of leukocyte malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) after the treatment. Statistics using F test and q test. Results: There was no significant difference in WBC (P> 0.05), and in the normal range. The content of MDA increased with the increase of concentration and time (P <0.05), and showed a dose-response relationship. The activity of SOD increased with the increase of concentration (P <0.05) No significant change. The activity of GSH-Px decreased with the increase of concentration and time (P <0.05), and the dose-response relationship. Conclusion: The determination of MDA, SOD and GSH-Px is earlier than leukocyte count, sensitive to reflect the toxicity of benzene on the body, and has certain significance for the early monitoring of workers exposed to benzene.