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以中医药学理论为指导,针对肥胖形成的主要原因,确定了健脾利湿、理气助运、消痰化饮的基本原则,选取茅苍术、香附、陈皮、枳壳、茯苓、泽泻、桂枝、法半夏、莱菔子9味中药组成苍附清臃汤,在充分肯定其临床效果的基础上进行了中药药理学研究。采用在大鼠日粮中添加丙基硫氧嘧啶和高含量脂肪的方法造成肥胖和高脂蛋白血症动物模型,每日在饮水中加入三种不同剂量(10g/只、8g/只、6g/只)的苍附清臃汤让其饮服,结果有效地对抗了丙基硫氧嘧啶和高脂日粮的影响。服用中药的大鼠,体重指数维持在正常范围之内,血清TC、TG和Apo B舍量显著低于对照组,血清HDL-C和Apo AI含量则显著高于对照组,显示该方具有良好的促进机体脂肪代谢功效。服用苍附清臃汤并不影响正常的饮食欲和消化吸收功能,也不影响正常的生长发育过程。3种不同剂量的苍附清臃汤均显示了促进机体脂肪分解代谢的良好效果,但从体重指数、血脂变化和脂肪消化吸收率等综合指标来看,每日服用8g/只剂量(1.00g/ml浓度)的效果最好,这一剂量相当于人每kg体重服用2g原中药。
Guided by the theory of traditional Chinese medicine, the basic principles of Jianpi Lishi, Liqi Yunyun, and Xiaoyu Huayin were identified according to the main causes of obesity. The techniques of Atractylodes lancea, Cyperus rotundus, Citrus, Shell, Poria, Alisma, were selected. Guizhi, Pinellia sinensis and Radix paeoniae radix are composed of 9 herbal medicines, Cangfu Qingchao Decoction. The pharmacology of traditional Chinese medicine was studied on the basis of fully affirming its clinical effects. The animal model of obesity and hyperlipoproteinemia was induced by adding propylthiouracil and high fat in rat diet. Three different doses (10g/bomb, 8g/mo, 6g) were added to drinking water daily. The Cangfu Qingxiong soup made it drinkable, which effectively counteracted the effects of propylthiouracil and high-fat diets. In rats taking traditional Chinese medicine, body mass index was maintained within the normal range, serum TC, TG, and Apo B levels were significantly lower than those of the control group. Serum HDL-C and Apo AI levels were significantly higher than those of the control group, indicating that the party had good results. Promotes body fat metabolism. Taking Cangfu Qingqi Decoction does not affect the normal dietary desire and digestion and absorption function, nor does it affect the normal growth and development process. The three different doses of Cangfu Qingqi Decoction all showed a good effect of promoting body fat catabolism, but from the combined indicators of body mass index, blood lipid changes and fat digestion and absorption rate, taking 8g/dose daily (1.00g The best effect is /ml concentration, which is equivalent to 2 g of the original Chinese medicine per kg of body weight.