[Objective] To research on the effects of Mn-SOD mimics on the seed germination, SOD activity, CAT activity and MDA content of Perilla frutescens. [Method] By simulating the saline-alkali condition (pH=8.0, 0.2% NaCl), Mn-SOD mimics and poly-aspartic manganese (II) within certain concentration range were used for the seed soaking and foliage spraying of P. frutescens. Foliage spraying was conducted for 7 d. The leave width, SOD activity, CAT activity and MDA content were detected. There were in all 3 cycles and leave width was only detected in the first cycle. [Result] Under salt stress, germination rate of 0.1 mg/L poly-aspartic manganese (II) seed soaking group was 5.33 times of that in no soaking group; the seed soaking and foliage spraying enhanced the leave width, SOD activity and CAT activity. 12.5 mg/L was the optimal spraying concentration. With the increase of spraying concentration of poly-aspartic manganese (II), MDA content reduced. [Conclusion] Under the test conditions, seed soaking and foliage spraying by poly-aspartic manganese (II) could effectively enhance the seed germination rate of P. frutescens, and improve the resistance to salt stress at seedling stage. [Objective] To research on the effects of Mn-SOD mimics on the seed germination, SOD activity, CAT activity and MDA content of Perilla frutescens. [Method] By simulating the saline-alkali condition (pH = 8.0, Mn-SOD mimics and poly-aspartic manganese (II) within certain concentration range were used for the seed soaking and foliage spraying of P. frutescens. Foliage spraying was conducted for 7 d. The leave width, SOD activity, CAT activity and MDA content were detected. There were in three cycles and leave width was only detected in the first cycle. [Result] Under salt stress, germination rate of 0.1 mg / L poly- aspartic manganese (II) seed soaking group was 5.33 times of that in no soaking group; the seed soaking and foliage spraying enhanced the leave width, SOD activity and CAT activity. 12.5 mg / L was the optimal spraying concentration. With the increase of spraying concentration of poly- aspartic manganese (II), MDA content reduced. [Conclusion] Under the test conditions, s eed soaking and foliage spraying by poly-aspartic manganese (II) could effectively enhance the seed germination rate of P. frutescens, and improve the resistance to salt stress at seedling stage.