脑血管痉挛是蛛网膜下腔出血后常见的并发症,其所致迟发性缺血性神经功能损害是患者致残和死亡的最主要原因。虽经多年研究,但其发病机制至今尚未完全阐明。一氧化氮、内皮素1、血红蛋白氧化产物及炎性反应均被认为参与致病过程。针对这些发病机制的治疗措施目前仍处于研究阶段,其在脑血管痉挛的防治中将发挥重要作用。 Cerebral vasospasm is a common complication after subarachnoid hemorrhage, leading to the most important cause of disability and death in patients with delayed ischemic neurological impairment. Although many years of research, but its pathogenesis has not yet fully elucidated. Nitric oxide, endothelin 1, hemoglobin oxidation products, and inflammatory responses are all considered to be involved in the pathogenic process. Therapeutic approaches to these pathogenesis are still at the research stage and will play an important role in the prevention and treatment of cerebral vasospasm.