给妊娠11 d 的大鼠经腹腔单次注入氚水,使体水氚浓度分别为5.55×10~6Bq/mL和5.55×10~5Bq/mL 体水,其1 d 龄和18 d 龄仔鼠累积吸收剂量分别为1.6—1.7Gy和0.16—0.17Gy,可引起其大脑和小脑皮质神经元细胞核及核周质中细胞器等超微结构明显损伤。90 d 龄时上述超微结构改变已消失,但仍可见增生的胶质细胞突起填于受损的神经毡结构中。 The rats in the 11th day of gestation were given a single intraperitoneal injection of water to make the body blister concentrations 5.55×10~6Bq/mL and 5.55×10~5Bq/mL body water, respectively, for 1 d and 18 d pups. Accumulative absorbed doses of 1.6-1.7 Gy and 0.16-0.17 Gy, respectively, can cause significant damage to the ultrastructure of the nucleus and organelles in the nucleus and periplasm of neurons in the brain and cerebellum. At 90 days of age, the above ultrastructural changes have disappeared, but proliferating glial cells are still seen filling the damaged neural mat structure.