【摘 要】
：
Long non-coding RNAs (lncRNAs) are widely involved in a variety of biological processes,including epithelial-mesenchymal transition (EMT).In the current study,we found that lncRNA small nucleolar RNA host gene 8 (SNHG8) was tightly correlated with EMT-ass
【机 构】
：
Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minist
论文部分内容阅读
Long non-coding RNAs (lncRNAs) are widely involved in a variety of biological processes,including epithelial-mesenchymal transition (EMT).In the current study,we found that lncRNA small nucleolar RNA host gene 8 (SNHG8) was tightly correlated with EMT-associated gene signatures,and was down-regulated by Zinc finger E-box-binding homeobox 1 (ZEB1) during EMT progress.Functionally,knockdown of SNHG8 induced EMT in epithelial cells,through destabilizing the CDH1 mRNA de-pendent on a 17-nucleotide sequence shared by SNHG8 and CDH1.In addition,analysis with public database showed that SNHG8 tended to be down-regulated in different cancer types and the lower expression of SNHG8 predicted poorer prognosis.Taken together,our study reports a ZEB1-repressed lncRNA SNHG8 which is important for stabilizing CDH1 mRNA,thereby maintaining the epithelial status of epithelial cells.
其他文献
In this paper,we obtain a necessary and sufficient condition for a U(n)-invariant complex Finsler metric F on domains in Cn to be strongly convex,which also makes it possible to investigate the relationship between real and complex Finsler geometries via
Let Ω (∈) R2 be a smooth bounded domain with 0 ∈ (e)Ω.In this paper,we prove that for any β ∈ (0,1),the supremum dx u∈W1,2(Ω),∫Ω supudx=0,∫Ω |▽u|2dx≤1 ∫Ω e2π(1-β)u2/|x|2β is finite and can be attained.This partially generalizes a well-known work of Chang
四川盆地中侏罗统沙溪庙组是盆地致密气勘探的重要领域,具有埋藏浅、投资少、效益高等特点,目前核心建产区主要位于川西地区,急需从盆地尺度对沙溪庙组致密气成藏条件进行系统梳理,拓展勘探领域.基于沙溪庙组烃源岩、天然气来源、断裂发育研究,系统分析盆地内不同地区源储匹配关系,建立成藏模式,指出有利勘探方向.研究认为,四川盆地中侏罗统沙溪庙组天然气由上三叠统须家河组、下侏罗统自流井组及中侏罗统凉高山组共同供烃,天然气类型自西向东依次以煤型气、油型气、油型气—煤型气混合气为主;不同区域间成藏模式由于地质条件差异有显著的
This paper presents a nonconforming finite element scheme for the planar biharmonic equation,which applies piecewise cubic polynomials (P3) and possesses O(h2) convergence rate for smooth solutions in the energy norm on general shape-regular triangulation
The multimodel inference makes statistical inferences from a set of plausible models rather than from a single model.In this paper,we focus on the multimodel inference based on smoothed information criteria proposed by seminal monographs (see Buckland et
鄂尔多斯盆地上古生界二叠系山西组具有丰富的煤系气资源,分析煤系气成藏地质条件,预测其蕴藏的资源潜力,对深化盆地非常规天然气的勘探有重要意义.以鄂尔多斯盆地山西组为目的层,基于岩心观察和单井地层发育特征分析,结合扫描电镜、X射线衍射分析、气体吸附实验等一系列分析测试成果,详细研究了烃源岩的地质、地球化学特征与储层的矿物组分、孔隙结构、物性特征,进而分析煤系气成藏地质条件并进行资源潜力预测.研究结果表明:(1)山西组烃源岩纵向上单层厚度较薄、层数多,平面上东厚西薄,烃源岩有机碳含量高,有机质类型为Ⅱ2、Ⅲ型,
准噶尔盆地油气发现程度差别大,天然气探明率较低.石炭系火山岩是盆地内目前天然气储量最多的层系,勘探证实其天然气成藏特征非常复杂.依据盆地内克拉美丽气田、五彩湾气田、阜康凹陷、滴北凸起等地区井的岩心、薄片鉴定及分析化验数据,在重点研究主力烃源岩松喀尔苏组b段特征的基础上,结合盆地内火山岩储层特征及天然气来源,分析石炭系火山岩天然气的成藏特征及勘探潜力.结果表明:石炭系烃源岩在五彩湾凹陷、滴水泉凹陷及东道海子凹陷等地区广泛分布,其中泥岩有机碳含量平均为1.58％;石炭系烃源岩有机质类型以Ⅲ型为主,大部分达到高
近年来,渤海湾盆地渤中坳陷天然气勘探相继取得重大突破,成为未来天然气勘探的重要区带.基于三维地震、测井、录井等资料和油气地球化学等分析化验资料,系统总结了渤中坳陷天然气藏特点及成藏主控因素,理清了天然气勘探潜力和下一步勘探方向.研究结果表明,渤中坳陷天然气藏主要分布于太古宇变质岩潜山、下古生界碳酸盐岩潜山和新生界古近系砂砾岩体中.天然气藏CO2含量差异大,低含CO2气藏为凝析气,高含CO2气藏为干气.大型天然气藏的形成受多因素联合控制:混合型烃源岩晚期快速熟化高强度生气是大型气藏形成的物质基础,多类型优质
苏里格气田苏14井区二叠系下石盒子组盒8段岩性气藏的主体储层为辫状河沉积体系形成的多种复杂叠置砂体,其叠置关系的认识对于气田的开发至关重要,如何制定合理工作制度成为气田高效开发的难题.通过分析气田储层砂体叠置关系,建立了不同类型生产井与叠置砂体分布关系模型,并利用数值模拟方法对不同砂体叠置模式下直井和水平井合理工作制度进行研究.结果表明,直井生产主要受到横向砂体叠置影响,纵向砂体叠置影响不大;纵向和横向砂体叠置均会对水平井生产带来明显影响;砂体叠置是造成苏里格气田稳产期短、产量开发早期就呈现递减的主要原因
鄂尔多斯盆地中东部地区奥陶系马家沟组发育巨厚的盐岩、膏岩沉积,封盖性能好,膏盐岩之下的碳酸盐岩一直是备受关注的重要勘探领域.在对区域构造沉积背景及沉积相带分布研究的基础上,以马家沟组马五段膏盐岩盖层之下的马四段碳酸盐岩为目标,主要开展了储层及成藏特征研究.研究认为:马四段白云岩分布主要受控于古隆起控制下的台内分异作用,发育滩相晶间孔型白云岩储层,马三段等层段的溶孔型白云岩储层也具有较好的储集性能;加里东期的风化剥蚀作用造成马四段白云岩与上古生界煤系烃源岩、奥陶系盐下海相烃源岩形成了空间配置关系,天然气成藏