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丁胺卡那霉素是目前临床上较好的半合成氨基糖苷类抗生素品种,近两年来先后在很多国家上市并广泛用于临床。国内虽由上海药物研究所与上海第四制药厂研究并试制出少量样品,但尚无正式产品。进口价格高达5万元/公斤。四川抗菌素工业研究所与成都制药四厂结合该地区原料情况,确定了合成路线,改进工艺,已制出一定数量的药理临床样品。本文介绍国产丁胺卡那霉素与进口日本丁胺卡那霉素抗菌作用的比较,认为效果完全一致。据悉近期将进行科研阶段鉴定,争取早日进入临床。 七十年代以来抗生素品种增长的很快,主要由于半合成抗生素的大量引入临床。国外氨基糖苷类抗生素结构改造工作已进入第三代产品,而我国这方面工作才刚刚开始。希望从事本专业的广大工作者一齐努力,创造加速发展半合成抗生素的条件,为我国在创制和仿制新抗生素或半合成抗生素方面做出更多的贡献。
Amikacin is currently clinically better semi-synthetic aminoglycoside antibiotic varieties, the past two years has many countries listed and widely used in clinical. Although a few samples have been researched and trial-produced by Shanghai Institute of Materia Medica and Shanghai No.4 Pharmaceutical Factory in China, there is no formal product yet. Import prices up to 50,000 yuan / kg. Sichuan Institute of Antibiotics and Chengdu Pharmaceutical Factory 4 combined with the situation of raw materials in the region to determine the synthesis route to improve the process, has produced a certain number of clinical pharmacological samples. This article describes the domestic amine amikacin and imported Japanese amikacin antibacterial effect comparison, that the effect is exactly the same. It is learned that the scientific research phase will be identified recently, for an early entry into the clinic. Since the seventies antibiotic varieties grew rapidly, mainly due to the large number of semi-synthetic antibiotics introduced into the clinic. Foreign aminoglycoside antibiotic structural transformation has entered the third generation of products, and our work in this area has just begun. Hope that the majority of workers engaged in this professional work together to create conditions to accelerate the development of semi-synthetic antibiotics for our country in the creation and imitation of new antibiotics or semi-synthetic antibiotics to make more contributions.