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目的探讨喉部肉瘤的临床病理特征及其预后影响因素。方法回顾性分析北京协和医院耳鼻咽喉科1990年1月至2008年12月期间住院治疗的13例喉部肉瘤患者的临床资料,分析肿瘤的临床病理特性,以Kaplan-Meier法进行生存率统计并分析临床分期和组织学分级与生存率的关系。结果喉部肉瘤患者以男性为主(9/13),含7种病理类型:恶性纤维组织细胞瘤、平滑肌肉瘤、横纹肌肉瘤、滑膜肉瘤、软骨肉瘤、神经纤维肉瘤、癌肉瘤。12例接受手术治疗,其中7例术后进行了放疗和/或化疗;另1例仅行放疗。全部病例平均随访29.3个月,其中5例出现局部复发,1例出现远处转移,5年生存率为38.0%。临床分期和组织学分级对生存率有明显影响(P<0.05)。结论喉部肉瘤预后差,临床分期和组织学分级与预后相关。
Objective To investigate the clinicopathological features and prognostic factors of laryngeal sarcoma. Methods The clinical data of 13 cases of laryngeal sarcoma hospitalized in Department of Otorhinolaryngology, Peking Union Medical College Hospital from January 1990 to December 2008 were retrospectively analyzed. The clinical and pathological features of the tumor were analyzed. The survival rate was calculated by Kaplan-Meier method. Analysis of clinical staging and histological grade and the relationship between the survival rate. Results Most of the patients with laryngeal sarcoma were male (9/13), including 7 pathological types: malignant fibrous histiocytoma, leiomyosarcoma, rhabdomyosarcoma, synovial sarcoma, chondrosarcoma, neurofibrosarcoma and carcinosarcoma. Twelve patients underwent surgery, of whom 7 underwent radiotherapy and / or chemotherapy and the other 1 underwent radiotherapy alone. All cases were followed up for an average of 29.3 months. Five cases had local recurrence, one case had distant metastasis, and the 5-year survival rate was 38.0%. The clinical stage and histological grade had a significant effect on the survival rate (P <0.05). Conclusion The poor prognosis of laryngeal sarcoma, clinical stage and histological grade and prognosis.