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以甲基丙烯酸丁酯为功能单体,二甲基丙烯酸乙二醇酯为交联剂,正丙醇和聚乙二醇400为致孔剂,偶氮二异丁腈为引发剂,在不锈钢管模具中制备聚合物整体柱(BMA-co-EDMA);以BMA-co-EDMA柱为萃取介质,利用聚合物整体柱微萃取技术,结合液相色谱-串联质谱法(LC-MS),建立了同时测定工业废水中6种喹诺酮药物残留量的分析方法.结果表明,在0.2～100.0 ng/mL质量浓度范围内,各目标物定量离子峰面积与其质量浓度呈现良好线性关系,相关系数在0.999 6～0.999 9之间,检出限在0.07～0.35 ng/L,定量限在0.2～1.0 ng/L,回收率在92.3％～98.6％,相对标准偏差在0.7％ ～ 3.7％.与其他方法相比,BMA-co-EDMA柱稳定性和重现性良好,可反复使用10次以上.“,”A polymer monolithic column is prepared in a stainless steel tube mold with butyl methacrylate as functional monomer,ethylene glycol dimethacrylate as crosslinking agent,n-propanol and polyethylene glycol 400 as porogen,and azo-bis-isobutyronitrile as initiator.The method to determine simultaneously 6 kinds of quinolones residues in industrial waste is developed by polymer monolithic microextraction combining with LC-MS through using BMA-coEDMA column as extractive medium.The results show that the peak area of quantitation ion of each target substance shows a good linear relationship with its concentration in the range of 0.2-100.0 ng·mL-1,with correlation coefficient ranging from 0.999 6 to 0.999 9.The detection limits range from 0.07 ng·L-1 to 0.35 ng·L-1.The quantitation limits range from ng·L-1 to 1.0 ng·L-1.The recovery rates range from 92.3％ to 98.6％,and the relative standard deviations range from 0.7％ to 3.7％.Compared with other methods,BMA-co-EDMA column has good stability and reproducibility,which can be used repeatedly more than 10 times.