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芍药甘草汤 (SGT)是常用中药方剂之一 ,在日本临床上常和一些西药合用。甘草酸(glycyrrhizin,GL)是SGT中主要的有效配糖体成分之一 ,经口给药后 ,GL在肠道内被肠内细菌代谢成活性产物甘草次酸(18β_glycyrrheticacid,GA)。本研究旨在利用大鼠 ,以GA的血药浓度为指标 ,探讨合用西药对SGT中GL的生物利用度的影响以及减少该影响的给药方案。笔者在本部分中首先考察了SGT中GL生物利用度在SGT连续给药下的变化。实验结果显示 ,GL生物利用度随着SGT的连续给药而逐渐上升。
Shaoyao Gancao Decoction (SGT) is one of the commonly used traditional Chinese medicine prescriptions, and in clinical practice in Japan often combined with some western medicine. Glycyrrhizin (GL) is one of the main active glycoside components in SGT. After oral administration, GL is metabolized by enterobacteria to the active product 18β-glycyrrhetic acid (GA). The purpose of this study was to investigate the effects of western medicine on the bioavailability of GL in SGT and the dosing regimen to reduce the effect by using the plasma concentration of GA as an index. In this section, the author first examines the changes of bioavailability of GL in SGT SGT continuous administration. The experimental results show that GL bioavailability gradually increases with the continuous administration of SGT.