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目的探讨焦虑、抑郁不良情绪与慢性乙肝发展和转归的关系。方法采用ＬＳＡＢ免疫组化和ＥＬＩＳＡ方法，检测了５２例慢性ＨＢＶ感染者肝细胞Ｃ－ｅｂｂＢ－２Ｐ１８５癌基因蛋白及血清ＨＢｅＡｇ，同时进行了ＳＡＳ和ＳＤＳ调查，结果与国内常模对照。结果Ｃ－ｅｒｂＢ－２Ｐ１８５癌基因蛋白阳性患者ＳＡＳ和ＳＤＳ总标准分均值Ｘ分别为４４．２１０±６．１２和４９．１３±９．８７，分数升高与国内常模之间有显著差异，（Ｐ＜０．０１）。结论提示焦虑、抑郁情绪在慢性乙肝的发生发展中可能起重要作用。
Objective To investigate the relationship between anxiety and depression and the development and prognosis of chronic hepatitis B. Methods The C-ebbB-2P185 oncoprotein and serum HBeAg were detected by LSAB immunohistochemistry and ELISA in 52 patients with chronic HBV infection. The results of SAS and SDS were compared with that of the domestic norm. Results The average standard scores of SAS and SDS for patients with positive C-erbB-2P185 oncoprotein were 44.210 ± 6.12 and 49.13 ± 9.87, respectively. There was a significant difference between the increased score and the national norm, (P <0.01). Conclusions suggest that anxiety and depression may play an important role in the occurrence and development of chronic hepatitis B.