进行了大扶康、大蒜素、大蒜油注射液抗深部真菌药效学的研究 ,采用沙氏培养基倍比稀释法观察不同接菌量、不同培养时间对药物最小抑菌浓度 (MIC)、最小杀菌浓度 (MBC)的影响 .用1× 10 5cfu/ /mL的接菌量 ,测定了大扶康、大蒜素、大蒜油注射液对 6 5株 (临床分离和标准菌株 )深部真菌的MIC50 、MIC90 、MBC50 、MBC90 .结果显示大扶康对白色念珠菌、热带念珠菌和新型隐球菌有较好的抑制作用 ,而对其它真菌无抑制作用和杀灭作用 .大蒜素、大蒜油注射液对所有真菌均有抑、杀作用 ,说明他们具有广谱抑、杀真菌的作用特点 .提示 :临床在不明确的严重真菌感染时 ,可联合用药 The anti-deep fungus pharmacodynamics of Dafukang, allicin, and garlic oil injections was studied. The Sabouraud medium was used for multiple dilutions to observe the minimum inhibitory concentration (MIC) of the drug and the culture time. Effects of the minimum bactericidal concentration (MBC). The MIC50 of the deep fungi of 65 strains (clinical isolates and standard strains) of DAIFUKANG, allicin, and garlic oil injection was determined using a bacterial colony of 1 × 10 5 cfu/mL. MIC90, MBC50, MBC90 The results showed that Dafukang had a good inhibitory effect against Candida albicans, Candida tropicalis and Cryptococcus neoformans, but it had no inhibitory and killing effects on other fungi. Allicin, garlic oil injection All fungi have inhibitory and killing effects, indicating that they have a broad-spectrum inhibitory and fungicidal action. Tip: Clinically, it can be used in conjunction with unclear severe fungal infections.