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ＮＨＥ－１是Ｎａ＋／Ｈ＋跨膜交换蛋白家族成员，是维持细胞内ｐＨ稳定的重要调节蛋白。ＮＨＥ－１多肽链全长含８１５个氨基酸残基，在其肽链分子结构上有二个功能区域，即Ｎ端功能域为Ｎａ＋／Ｈ＋交换的必要条件；Ｃ端功能域决定Ｎａ＋／Ｈ＋交换的ｐＨ调定点，同时也是ＮＨＥ－１活性调节的效应位点。一些重大疾病的病理生理与ＮＨＥ－１的活性改变或表达水平有关。
NHE-1 is a member of the Na+/H+ transmembrane exchange protein family and is an important regulatory protein that maintains intracellular pH stability. NHE-1 polypeptide chain contains 815 amino acid residues in its full length, and has two functional regions in its peptide chain molecular structure, ie N-terminal functional domain is a necessary condition for Na+/H+ exchange; C-terminal functional domain determines Na+/H+ exchange The pH set point is also an effector site for NHE-1 activity regulation. The pathophysiology of some major diseases is related to the altered or expressed levels of NHE-1 activity.