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1955年Zollinger和Ellison报告一组具有异常部位消化性溃疡、胃酸分泌过多和胰腺非特异性胰岛细胞肿瘤三联征的病例;以后人们称之为Zollinger—Ellison综合症(以下简称ZES)。本文主要综述治疗新进展如下: 诊断对ZES的诊断随着科学的发展而不断改进,目前一般多采用8个步骤:1.有下列表现之一者为可疑病例:(1)溃疡为多发性、多部位溃疡,多在易发部位以外的地方;(2)消化性溃疡经积极内科治疗无效并易反复出血者;(3)消化性溃疡伴有水泻或脂泻;(4)消化性溃疡伴有高钙血症;(5)消化性溃疡手术后很快发生溃疡;(6)有MEA-I(multiple endocrine adenomatosistype I)家族史者。2.对以上患者进行胃液分析
In 1955, Zollinger and Ellison reported a group of patients with peptic ulcer, hypersecretion, and triad of pancreatic nonspecific islet cell tumor; later known as Zollinger-Ellison Syndrome (hereinafter referred to as ZES). This review summarizes the progress of the treatment are as follows: Diagnosis The diagnosis of ZES with the continuous improvement of scientific development, the current general use of eight steps: 1. One of the following manifestations of suspicious cases: (1) ulcers are multiple, Multi-site ulcers, and more prone areas outside the place; (2) peptic ulcer by active medical treatment ineffective and easy to repeated bleeding; (3) peptic ulcer associated with watery diarrhea or celiac; (4) peptic ulcer Accompanied by hypercalcemia; (5) peptic ulcer ulcer soon after surgery; (6) have a family history of MEA-I (multiple endocrine adenomatosistype I). 2. Gastric fluid analysis of these patients