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目的 探讨 Graves病 ( GD)患者外周血可溶性凋亡相关蛋白 Fas( s Fas)的变化特点及其临床意义。方法 采用酶联免疫吸附法检测 47例治疗不同时期 GD病患者和 2 0例正常人外周血血清 s Fas的含量。结果 1GD患者血清 s Fas含量明显高于正常对照 ( P<0 .0 1) ;与 GD初发组相比 ,GD缓解组和临床痊愈组患者血清 s Fas逐步降低 ,彼此之间存在显著性差异 ( P<0 .0 1) ;2血清 s Fas与 GD患者促甲状腺素受体抗体 ( TRAb)水平呈显著正相关 ( r=0 .41,P<0 .0 5 ) ,而与患者年龄、甲状腺激素 ( FT3、FT4)、促甲状腺激素 ( TSH)、甲状腺球蛋白抗体 ( TGAb)、甲状腺过氧化物酶抗体 ( TPOAb)之间无明显相关关系。结论 GD患者体内存在 s Fas的异常表达 ,由此加重甲状腺肿大和局部免疫功能的紊乱 ,在 GD的发生发展中发挥重要作用
Objective To investigate the characteristics and clinical significance of the changes of soluble Fas (sFas) in the peripheral blood of patients with Graves disease (GD). Methods The serum levels of s-Fas in 47 patients with GD disease and 20 normal controls were detected by enzyme-linked immunosorbent assay (ELISA). Results The level of s-Fas in 1GD patients was significantly higher than that in controls (P <0.01). Compared with the initial GD group, the levels of s-Fas in GD remission group and clinical remission group were gradually decreased, and there was a significant difference between them (P <0.01) .2 There was a significant positive correlation between serum s-Fas and thyrotropin-receptor antibody (TRAb) level in patients with GD (r = 0.41, There was no significant correlation between FT3, FT4, TSH, TGAb and TPOAb. Conclusion The abnormal expression of s Fas in GD patients aggravates the disorder of goiter and local immune function and plays an important role in the genesis and development of GD