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目的 探讨老年糖尿病患者自由基和抗氧化能力的变化及其与微血管并发症的关系。 方法 测定 6 5例老年糖尿病患者和 6 5例健康老年对照者血浆或红细胞中脂质过氧化物 (LPO)、超氧化物岐化酶 (SOD)、过氧化氢酶 (CAT)、谷胱甘肽过氧化物酶 (GSH PX)、维生素C(VC)、维生素E(VE)、β 胡萝卜素 (β CAR)、谷胱甘肽 (GSH) ,同时测定患者的空腹血糖、餐后 2h血糖、糖化血红蛋白(HbA1c)、空腹和餐后 2hC肽、血脂、尿微量白蛋白排泄率、肌电图。 结果 老年糖尿病患者LPO(42 97± 6 99)nmol/g高于健康老年组 (31 5 9± 7 4 4 )nmol/g ,SOD(1712 4 4± 15 7 0 4 )U/L、CAT(2 17 0 1± 2 9 36 ) μg/g、GSH PX(2 1 0 1± 3 38)× 10 -10 U/RBC、VC(40 98± 10 5 1) μmol/L、VE(16 4 4± 2 4 5 ) μmol/L、β CAR(1 19± 0 2 3) μmol/L、GSH(0 98± 0 16 )nmol/L低于健康老年组〔分别为 (192 8 38± 14 3 4 4 )U/L、(2 6 4 4 0± 6 3 5 5 ) μg/g、(2 5 16± 6 4 1)× 10 -10 U/RBC、(5 2 2 3± 10 5 1) μmol/L、(2 3 0 4± 5 38) μmol/L、(1 6 3± 0 4 0 ) μmol/L、(1 2 5± 0 2 0 )nmol/L〕 ,合并糖尿病微血管并发症者变化更加明显 ,LPO和年龄呈正相关 (r=0 310 ,P <0 0 5 ) ,SOD、C
Objective To investigate the changes of free radicals and antioxidant capacity in elderly patients with diabetes mellitus and its relationship with microvascular complications. Methods The levels of lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) in plasma and erythrocytes of 65 elderly diabetic patients and 65 healthy controls were measured. GSH PX, VC, VE, β CAR and GSH were measured. The fasting plasma glucose, 2-hour postprandial blood glucose, Glycated hemoglobin (HbA1c), fasting and postprandial 2hC peptide, lipids, urinary albumin excretion rate, EMG. Results Compared with healthy elderly group, LPO (42 97 ± 6 99) nmol / g in elderly diabetic patients was significantly higher than that in healthy elderly patients (31 5 9 ± 74 4 nmol / g, SOD 1712 4 4 15 7 0 4 U / L, CAT 2 17 0 1 ± 2 9 36 μg / g, GSH PX (2 1 0 ± 3 38) × 10 -10 U / RBC, VC (40 98 ± 10 5 1) μmol / L and VE (24 ± 14) μmol / L, β CAR (1 19 ± 0 2 3) μmol / L, and GSH (98 ± 0 16) nmol / L were lower than those in healthy elderly group (192 8 38 ± 14 3 4 4) U / L, (2 6 4 4 0 ± 6 3 5 5) μg / g, (2 5 16 ± 6 4 1) × 10 -10 U / RBC, (5 2 2 3 ± 10 5 1) μmol / L, (2300 ± 538) μmol / L, (1633 ± 040μmol / L, (125 ± 0.220) nmol / L〕 with or without microvascular complications More clearly, LPO was positively correlated with age (r = 0 310, P <0 05), SOD, C