多发性骨髓瘤(MM)是浆细胞恶性克隆性疾病,发病率约为1/10万,发病年龄50～60岁多见,男女比例约为3∶2。并发症主要包括:贫血、感染、骨痛、出血和血栓。出血和血栓形成尤其是严重出血和深静脉血栓形成严重影响患者的生存质量,甚至威胁生命。本文就MM的凝血异常作一介绍,希望引起临床血液工作者的重视。正常凝血 Multiple myeloma (MM) is a plasma cell malignant clonal disease, the incidence of about 1/10 million, the onset of age 50 to 60 years old more common, the ratio of men and women is about 3: 2. Complications include anemia, infection, bone pain, bleeding and thrombosis. Bleeding and thrombosis, especially severe bleeding and deep venous thrombosis, seriously affect the quality of life of patients, and even life-threatening. This article on the coagulation abnormalities MM made an introduction, hoping to arouse the attention of clinical blood workers. Normal coagulation