梅毒螺旋体(TP)是梅毒的病原体,本文介绍近年来有关TP致病性与免疫性的一些进展。 TP的致病性 TP的致病机理尚不十分清楚,它没有外毒素。虽然有些学者曾报道,TP的外鞘,除含蛋白质与类脂外,尚有抗原与免疫性特异的多糖体,但迄今并未证实螺旋体的脂多糖具有革兰氏阴性细菌脂多糖的内毒素活性。近来研究认为TP的致病可能与其荚膜样物质和粘多糖酶有关。一、荚膜样物质 swain等发现将TP置于蒸馏水中,菌体并不肿胀或变形。在某些血清学试验中,用新分离的TP往往检测不出抗原抗体 Treponema pallidum (TP) is the pathogen of syphilis, this article describes some of the recent progress on the TP pathogenicity and immunity. Pathogenicity of TP Pathogenic mechanism of TP is not yet clear, it has no exotoxin. Although some scholars have reported that the outer sheath of TP, in addition to protein and lipid, there are antigenic and immune-specific polysaccharides, but so far has not confirmed the spirochete lipopolysaccharide with Gram-negative bacterial lipopolysaccharide endotoxin active. Recent studies suggest that the pathogenesis of TP may be related to its capsular material and mucolytic enzyme. First, capsular material Swain found that TP will be placed in distilled water, bacteria do not swollen or deformed. In some serological tests, antigen antibodies are often undetectable with newly isolated TPs