我们采取反向合成胶乳以纳米微囊用水溶解材料制备药物发送系统 关于我们的研究工作,已经发表了一系列论文 在我们所用的材料中,透明质酸(HA)是在人体软组织中的一种一致性的氨基多糖,它具有相当多的生物相容性质,在医学中有良好的应用前景 然而,它的某些性质,例如力学拉伸强度低,在人体中留存的时间短等缺点,阻碍了它的应用 所以,对于HA还需要进行化学改造去降低它的可溶性并减缓它的人体吸收速度 化学改造的组要方法是交叉连锁,酯化作用,和交叉连锁酯化的HA 为了用透明质酸(HA)纳米 微囊制备药物发送系统,其关键点是应用各种不同的微孔制备HA凝胶 因此,必须选择合适的交叉连锁作用剂,并研究交叉连锁过程的规律性 我们应用divinylsulphone(DVS)作为交叉连锁剂去交叉连锁HA,以实现扩大分子量(Mr)的目的,以改进它的力学稳定性和延长它在液体环境中的留存时间 这一凝胶系列可以作为研究和制备药物载体的材料 We take a reverse synthetic latex in nanocapsules to prepare drug delivery systems with water-soluble materials. For our work, a series of papers have been published. Among the materials we use, hyaluronic acid (HA) is one of the soft tissues in humans Consistent amino polysaccharide, which has a considerable number of biocompatible properties, has good application prospects in medicine However, some of its properties, such as mechanical tensile strength is low, short retention time in the human body and other shortcomings, hinder Therefore, HA also needs to be chemically modified to reduce its solubility and reduce its absorption rate of the human body. The chemical modification method is cross-linked, esterified, and cross-linked esterified HA in order to use the transparent The key point of acid (HA) nanocapsules for preparing drug delivery system is to use various micro-pores to prepare HA gel. Therefore, we must select the appropriate cross-linking agent and study the regularity of cross-linkage process. We use divinylsulphone DVS) as a cross-linker to cross-link HA in order to achieve the purpose of increasing the molecular weight (Mr) to improve its mechanical stability and to extend it in the liquid ring The residence time in this series of gels prepared as research and pharmaceutical carrier materials