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血管生成现象在原位肿瘤及其转移瘤的快速生长过程中具有重要作用[1]。切除原位肿瘤会导致休眠状态的转移瘤呈爆发性生长。这种现象不依赖任何特异的免疫反应，是肿瘤自身抑制转移瘤生长，被称作伴发性肿瘤抵御（concomitautturnorresistance）[2]。进一步研究证实原发肿瘤同时
Angiogenesis plays an important role in the rapid growth of orthotopic tumors and their metastases [1]. Removal of an orthotopic tumor results in an explosive growth of the dormant metastases. This phenomenon does not depend on any specific immune response. It is the tumor itself that inhibits the growth of metastatic tumors and is called concomitautional resistance (2). Further studies confirmed the primary tumor at the same time