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目的探讨儿童登革热(DF)合并肝功能损害的临床特征。方法对2014年8—12月我院感染科收治住院的78例儿童DF的临床资料进行回顾性分析。结果并发肝功能损害36例(46.15%),其中血清丙氨酸转氨酶(ALT)升高24例(30.77%),血清天冬氨酸转氨酶(AST)升高33例(42.31%);27例(75%)ALT/AST病程2周内恢复正常,9例于1月复查恢复正常。仅有1例总胆红素(TBIL)升高80.8μmol/L,直接胆红素升高为主,1周后恢复正常。肝功能损害组较无肝功能损害组在外周血白细胞水平、血小板水平差异有统计学意义(P<0.05)。结论儿童DF并肝功能损害较普遍,以轻度损害为主。与年龄、性别、皮疹、外周血白细胞、血小板有相关性。
Objective To investigate the clinical features of dengue fever (DF) combined with liver dysfunction in children. Methods A retrospective analysis was performed on the clinical data of 78 children admitted to our department of infectious diseases from August to December 2014 in our hospital. RESULTS: Thirty-six patients (46.15%) had hepatic dysfunction. Serum alanine aminotransferase (ALT) increased in 24 (30.77%) and serum aspartate aminotransferase (AST) increased in 33 (42.31% (75%) ALT / AST course returned to normal within 2 weeks and 9 cases returned to normal in January. Only one case of total bilirubin (TBIL) increased 80.8μmol / L, the main direct bilirubin, returned to normal after 1 week. There were significant differences in peripheral blood leukocyte and platelet between the group of liver dysfunction and the group without liver dysfunction (P <0.05). Conclusion Children with DF and liver damage more common, with mild damage-based. And age, gender, rash, peripheral white blood cells, platelets are related.