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血清阴性脊椎关节炎(SSA)为HLA—B27表型的一类关节病,病因与遗传控制的免疫缺陷有关。37例男病人包括关节强直性脊椎关节炎18例,Reiter氏病14例,牛皮癣性关节炎5例,每周用左旋咪唑3天,每天150毫克治疗,以促进免疫。病人按随机对照交叉研究方法,用药与用安慰剂各12周。整个6月期间仍继续用对症治疗。临床疗效根据累计的关节指数、脊椎测量、晨僵及疼痛程度来测定。左旋唑咪治疗可使这些指标明显改善。焦磷酸锝(Tc~(99))关节扫描及X线检查等表明治疗期间病变无发展。左旋咪唑治疗后,IgM水平明显降低,安慰剂为188±56,用左旋咪唑为136±38,P<0.014;IgA、IgG改变则不大。活性玫瑰花结形成细胞百分比由12.4±5.4升为17.2±
Serum-negative spondyloarthritis (SSA) is a type of arthrosis of the HLA-B27 phenotype that is associated with genetic-controlled immunodeficiency. Thirty-seven male patients included 18 cases of ankylosing spondyloarthritis, 14 Reiter’s disease and 5 cases of psoriatic arthritis. Levamisole was administered weekly for 3 days and 150 mg daily to promote immunity. Patients were randomized to a crossover study of medication and placebo for 12 weeks. He continued symptomatic treatment throughout June. Clinical efficacy was measured based on cumulative joint index, spine measurements, morning stiffness and pain. Levofollamide treatment can significantly improve these indicators. Technetium pyrophosphate (Tc ~ (99)) joint scan and X-ray examination showed no progression of lesions during treatment. After levamisole treatment, IgM levels were significantly reduced at 188 ± 56 for placebo and 136 ± 38 with levamisole, P <0.014; IgA and IgG did not change significantly. The percentage of active rosette forming cells increased from 12.4 ± 5.4 to 17.2 ±