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流行病学调查和实验室研究结果表明,石棉除能引起肺纤维化(即石棉肺)以外,还是一种完全致癌物,兼有启动剂和促癌剂的作用。但石棉又与其它致癌物不同,它不能绣导基因突变。本文研究了气管内植入石棉的大鼠290d后其骨髓细胞的遗传学改变。所用材料为采自印度当地石棉厂粒径小于30μm的温石棉,实验选用体重120±10 g的雌性大鼠,分成2组,第1组接受气管内植入温石棉(5 mg/0.5 ml中性盐溶液),另一组只接受中性盐溶液作为对照。2组动物饮食条件相同,于一带有空调昼夜各12 h重复循环的房间里饲养290 d后,每
Epidemiological investigations and laboratory studies have shown that asbestos in addition to causing lung fibrosis (asbestosis), or a complete carcinogen, both promoters and promoters role. However, asbestos and other carcinogens, it can not be embroidered mutagenesis. In this paper, we studied the genetic changes of bone marrow cells after tracheal implantation of asbestos in rats for 290 days. The material used was chrysotile asbestos particle diameter less than 30μm collected from Indian asbestos factory. Female rats weighing 120 ± 10g were selected and divided into two groups. Group 1 received endotracheal implantation of chrysotile (5 mg / 0.5 ml Saline solution) and the other group received only neutral saline solution as a control. The animals in the two groups had the same dietary conditions and were housed for 290 days in a room with air-conditioned day-night and 12-hour repetitive cycles, each