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目的 评估肝门胆管癌行单侧肝管引流术后肝功能的恢复情况。方法 回顾性分析 5 8例资料完整患者的临床资料 ,比较单侧引流组 (n =2 7)及双侧引流组 (n =31)手术前后肝功能的变化。结果 两组术前各项肝功能指标对比无显著性差异。双侧引流组各项肝功能指标至术后 6周时基本达正常范围。单侧引流组术后血浆白蛋白渐恢复正常 ,胆红素及谷丙转氨酶呈下降趋势 ,至术后 2周时略高于正常范围 ,血清碱性磷酸酶术后 2周内渐下降 ,随后又升高。结论 单侧肝管引流对肝门胆管癌术后肝功能的恢复具有一定的作用 ,这类手术对不能行根治性切除的患者有一定的治疗意义。
Objective To evaluate the recovery of hepatic function after unilateral hepatic duct drainage in patients with hilar cholangiocarcinoma. Methods The clinical data of 58 patients with complete data were retrospectively analyzed. The changes of liver function before and after unilateral drainage (n = 27) and bilateral drainage (n = 31) were compared. Results There was no significant difference between the two groups in preoperative liver function indexes. Bilateral drainage group of liver function indicators to 6 weeks after the basic up to the normal range. Serum albumin gradually returned to normal after unilateral drainage, and bilirubin and alanine aminotransferase (ALT) tended to descend to slightly higher than the normal range at 2 weeks after operation. Serum alkaline phosphatase gradually decreased within 2 weeks after operation, It rises again. Conclusion Unilateral hepatic duct drainage has a certain effect on the recovery of postoperative liver function in patients with hilar cholangiocarcinoma. This type of surgery has certain therapeutic significance for patients who can not be treated by radical resection.