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为了观察乙型肝炎 (乙肝 )病毒 (HBV)易感者接种 2剂血源乙肝疫苗的远期免疫效果 ,1985年 4月 ,在正定县某村 ,对整个人群采血并检测乙肝病毒表面抗原 (HBsAg)、乙肝病毒表面抗体 (抗 HBs)和乙肝病毒核心抗体 (抗 HBc)。对 3项指标均阴性的 132人接种 2剂乙肝疫苗 ,按 0、3个月免疫程序 ,每剂 10 μg/ml,于首剂免疫后 6个月、12个月和 14年检测HBsAg、抗 HBs和抗 HBc ,并进行流行病学调查。结果显示 :乙肝疫苗免疫后 6个月时 ,抗 HBs阳性率 (S/N≥ 2 1)为 10 0 % ,未检出HBsAg阳性者 ;12个月时 ,<2 0岁组的抗 HBs阳性率 (S/N≥ 2 1)为94 3% ;≥ 2 0岁组则为 74 2 % ,二者差异有显著的统计学意义 (χ2 =5 16 ,P <0 0 5 ) ,未检出HBsAg阳性者 ;14年时 ,抗 HBs阳性率降为 5 9 31% (S/N≥ 2 1)或 18 6 % (S/N≥ 10 0 ) ,各年龄组之间差异无显著的统计学意义 (χ2 =1 2 4 ,P >0 0 5 ) ,检出HBsAg阳性者 1例 ,3个月后复检阴性 ,未发现肝病病人。说明HBV易感者接种 2针乙肝疫苗可取得较好的免疫效果。
In order to observe the long-term immunization effect of hepatitis B virus (HBV) susceptible inoculated with 2 doses of Hepatitis B vaccine in April 1985, in a village in Zhengding County, blood was collected from the entire population and tested for hepatitis B virus surface antigen HBsAg), hepatitis B virus surface antibodies (anti-HBs) and hepatitis B virus core antibodies (anti-HBc). 132 patients who were negative for all three indicators were vaccinated with two doses of hepatitis B vaccine. HBsAg was tested at 6 months, 12 months and 14 years after the first dose of immunization according to the immunization schedule of 0 and 3 at 10 μg / ml per dose HBs and anti-HBc, and conduct epidemiological investigations. The results showed that the positive rate of anti-HBs (S / N≥2 1) was 10% at 6 months after the hepatitis B vaccine immunization and no positive HBsAg was detected. At 12 months, the anti-HBs positive (S / N≥2 1) was 94 3%; while ≥ 20 years old was 74 2%, the difference was statistically significant (χ2 = 5 16, P <0 05), not detected HBsAg positive; 14-year, anti-HBs positive rate was reduced to 5 931% (S / N≥2 1) or 18 6% (S / N≥10 0), no significant statistical difference between the age groups Significance (χ2 = 1 2 4, P> 0 0 5), HBsAg positive was detected in 1 case, 3 months after the retest was negative, no liver disease patients. That HBV susceptible vaccination 2-pin hepatitis B vaccine can achieve better immune effect.