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伯喹是8-氨基喹啉类中最有效的抗疟药,尚未发现原虫对它有抗性,但由于其治疗剂量接近中毒剂量,产生了临床问题。伯喹的毒性副作用主要有以下几种表现。胃肠道反应:空腹服药易出现腹痛,因此以饭后给药为宜。反应程度与剂量有关。每日15mg,连服14天,3%病人有轻度腹痛;而每日服22.5mg,12%患者出现轻度至中等度腹痛;每日服30mg和60mg的患者腹痛发生率分别为10%和18%。服较大剂量者可引起严重腹痛,且伴食欲减退、恶心和呕吐。
Primogen is the most effective antimalarial in 8-aminoquinolines and no protozoan has been found to be resistant to it, but clinical problems have arisen due to its therapeutic dose approaching the toxic dose. The primary side effects of primaquine toxicity have the following performance. Gastrointestinal reactions: fasting medication prone to abdominal pain, it is appropriate to postprandial administration. The degree of response and dose. Daily 15mg, and even served 14 days, 3% of patients had mild abdominal pain; and daily serving 22.5mg, 12% of patients with mild to moderate abdominal pain; 30mg and 60mg daily intake of abdominal pain were 10% And 18%. Serve larger doses can cause severe abdominal pain, and with loss of appetite, nausea and vomiting.