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将牛骨形成蛋白(bBMP)与多孔羟基磷灰石(HA)结合制成 bBMP-HA 复合人工骨,植入狗股骨缺损区,植入后2,4,8,16,24周,采用组织学、扫描电子显微镜及~(43) Ca 同位素示踪综合考查其骨修复过程,并以单纯 HA 作为对照。结果发现,各实验程期 bBMP-HA 材料内新骨形成量均明显多于单纯 HA 对照组,bBMP-HA 植入后早期诱导骨形成较活跃,实验证明 bBMP-HA 复合人工骨具有良好的诱导成骨能力,并能促进骨缺损的修复。
The bBMP-HA composite artificial bone was made by combining bBMP with porous hydroxyapatite (HA), implanted into the defect area of dog femur, and at 2, 4, 8, 16 and 24 weeks after implantation, Scanning electron microscopy and ~ (43) Ca isotope tracing were used to examine the bone repair process. HA alone was used as a control. The results showed that the amount of new bone formation in the bBMP-HA material during each experimental period was significantly higher than that in the HA control group. The bBMP-HA implanted early induced bone formation more active. The experimental results show that the bBMP-HA composite artificial bone has good induction Osteogenic ability, and can promote the repair of bone defects.