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目的探讨给予妊娠8~10周流产患者使用不同剂量米非司酮的临床治疗效果。方法选取2012年1月至2013年12月我院计划生育中心收治的妊娠8~10周流产患者72例,依照随机数字表法分为两组,A组患者给予300mg剂量的米非司酮,B组患者给予150 mg剂量的米非司酮,患者均配合服用米索前列醇,对比两组患者的临床疗效及不良反应发生率。结果经过相应治疗,A组患者的流产有效率高于B组,胚胎排出时间短于B组,差异均有统计学意义(P<0.05);两组患者不良反应相比,差异无统计学意义(P>0.05)。结论对于妊娠8~10周流产患者来说,运用大剂量(300 mg)米非司酮配伍常规剂量的米索前列醇,治疗效果明显,能提高流产率,缩短胚胎排出时间,安全且不良反应少。
Objective To investigate the clinical effects of different doses of mifepristone given to abortion patients during 8-10 weeks gestation. Methods From January 2012 to December 2013, 72 cases of pregnancy induced abortion in our hospital from 8 to 10 weeks of gestation were divided into two groups according to the random number table. Patients in group A were given mifepristone 300 mg, Group B patients were given 150 mg dose of mifepristone, patients were treated with misoprostol, compared the clinical efficacy and incidence of adverse reactions in both groups. Results After treatment, the abortion rate in group A was higher than that in group B, and the time of embryo discharge was shorter than that in group B (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). CONCLUSIONS: For misoprostol at 8-10 weeks of gestation, the use of high dose (300 mg) mifepristone in combination with conventional doses of misoprostol results in significant abortion rates, shortened embryo delivery times, safe and adverse reactions less.