目的　评价促进骨形成的药物与成骨细胞分化诱导剂联用对绝经后骨质疏松的潜在治疗作用。方法　观察氟钙剂（０４５ ｎｇ Ｆ＋ １３５６ ｍ ｇ Ｃａ２＋ ）／（ｋ·ｄ）单独应用（Ｏ＋ Ｆ）以及与１，２５ 双羟维生素Ｄ（１３５ ｐｍ ｏｌ／ｄ 皮下注射）联用（Ｏ＋ Ｆ＋ Ｄ）对去卵巢（ＯＶＸ）大鼠胫骨近端次级松质骨骨计量学指标和股骨中段骨生物力学性质的影响。结果　与ＯＶＸ组比较，Ｏ＋ Ｆ组、Ｏ＋ Ｆ＋ Ｄ组骨小梁面积百分比（％ Ｔｂ Ａｒ）、骨小梁宽度（Ｔｂ Ｗｉ）、骨小梁数量（Ｔｂ Ｎ），成骨细胞表面（％ Ｏｂ Ｐｍ ）、骨小梁分离度（Ｔｂ Ｓｐ）均明显增加，而吸收侵蚀表面（％ ＥＰｍ ）显著降低（Ｐ＜ ００５， Ｐ＜ ００１，Ｐ＜０００１）；平均骨壁宽度（Ｗ Ｗｉ）在Ｏ＋ Ｆ组无显著变化，而在Ｏ＋ Ｆ＋ Ｄ组则明显增加。与假手术组比较，Ｏ＋ Ｆ组的矿化延迟时间（ＭＬＴ）明显增加（Ｐ＜ ００５），而Ｏ＋ Ｆ＋ Ｄ组无显著变化，Ｏ＋ Ｆ和Ｏ＋ Ｆ＋ Ｄ组均未见股骨干力学强度下降。结论　上述两种处理均有防止去卵巢所致的骨量丢失和加速骨吸收、保护小梁骨显微结构、刺激骨形成的作用，而联合用药作用更为显著，并且消除了单用氟钙剂所致的潜在的矿化缺陷。两种 Objective To evaluate the potential therapeutic effect of drugs that promote bone formation and osteoblast differentiation inducer on postmenopausal osteoporosis. Methods Fluoride (045 ng F + 1356 m g Ca2 +) / (k · d) alone was used in combination with 1,25-hydroxyvitamin D (subcutaneous injection at 135 pm ol / d) (O + F + D) on the measurement of secondary osteosynthesis and the biomechanical properties of femur in the proximal tibia of ovariectomized rats. Results Compared with the OVX group, the percentage of trabecular area (% Tb Ar), trabecular area (Tb Wi), trabecular number (Tb N), and the surface of the osteoblast (% Ob Pm) and trabecular separation (Tb Sp) were significantly increased, while the absorption erosion surface (% EPm) significantly decreased (P <005, P <001, P <0001) (W Wi) did not change significantly in O + F group, but significantly increased in O + F + D group. Compared with the sham operation group, the mineralization delay time (MLT) in O + F group increased significantly (P <005), but there was no significant change in O + F + D group, and no mechanical strength of femoral shaft was found in O + F and O + F + D groups decline. Conclusions Both of the above two treatments have the effect of preventing bone loss and accelerating bone resorption caused by ovariectomy, protecting the trabecular bone microstructure and stimulating bone formation, and the combined treatment effect is more obvious, and the elimination of single calcium fluoride Potential mineralization caused by defects. Two kinds