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泪液渗透压是维持泪膜稳定的重要因素.随着泪液渗透压检测技术的发展,关于泪液渗透压与相关疾病关系的研究越来越多,将泪液渗透压检测用于干眼等眼表相关疾病的诊断优势将更加明显.目前不同泪液渗透压检测方法以及诊断干眼的泪液渗透压临界值正受到临床医师的关注,关于分析性别、年龄、眼别、昼夜变化、泪液取样部位以及泪液采集间隔时间对泪液渗透压影响的研究进展已有报道.就泪液渗透压与干眼诊断、糖尿病、翼状胬肉以及角膜接触镜的研究进展进行综述.“,”Tear osmolarity is an important factor in maintaining tear film stability.With the development of testing technology for tear osmolarity,more researches on tear osmolarity and related diseases were reported, and the advantages of tear osmolarity in diagnosing dry eye and related diseases appear to be obvious.The testing technology of tear osmolarity and the tear osmolarity critical value in dry eye diagnosis are concerned by many ophthalmologists.The effects of some factors on diagnosis of eye diseases including gender, age, eye side, diurnal variation, sampling position and collecting time of tear have been researched.The research progress in the relationship between tear osmolarity and dry eye diagnosis, diabetes,pterygium, coneal contact lens were summarized.