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目的探讨血清中甲状旁腺激素(i PTH)、视黄醇结合蛋白(sRBP)及β2-微球蛋白(β2-MG)水平与慢性肾功能衰竭(CRF)的相关性。方法选取确诊为慢性肾功能衰竭的患者100例作为观察组,另选取体检健康的志愿者100例为健康组,比较2组血清i PTH、sRBP及β2-MG水平,分析CRF患者血清i PTH、sRBP及β2-MG水平三者的相关性。结果观察组血清i PTH、sRBP和β2-MG三者水平均高于健康组,差异均有统计学意义(P<0.05或P<0.01);血清i PTH水平与sRBP和β2-MG水平呈明显正相关(r=0.6889、07456,P<0.05),sRBP水平和β2-MG水平呈明显正相关(r=0.8123,P<0.05)。结论血清中i PTH、sRBP和β2-MG三者水平在慢性肾功能衰竭时都显著性的增加,以上三项指标均可用于肾功能是否衰竭的判断指标。
Objective To investigate the correlation between serum parathyroid hormone (i PTH), retinol binding protein (sRBP) and β2-microglobulin (β2-MG) levels and chronic renal failure (CRF). Methods 100 cases diagnosed as chronic renal failure were selected as the observation group. 100 healthy volunteers were selected as healthy group. The serum levels of i PTH, sRBP and β2-MG were compared between the two groups. The serum levels of i PTH, sRBP and β2-MG levels of the three correlation. Results The serum levels of i PTH, sRBP and β2-MG in the observation group were significantly higher than those in the healthy group (P <0.05 or P <0.01). The serum levels of i PTH, sRBP and β2-MG were significantly higher (R = 0.6889,07456, P <0.05). There was a significant positive correlation between sRBP level and β2-MG level (r = 0.8123, P <0.05). Conclusion Serum levels of i PTH, sRBP and β2-MG are significantly increased in patients with chronic renal failure, the above three indicators can be used to determine whether the failure of renal function indicators.