目前很多医疗单位的用药还处于每日3至4次,每次一片或一格的传统均分法给药。研究时间用药,以充分发挥药物的疗效,减少服药次数,降低毒性,使药物在最佳剂量及最佳服药时间内发挥更好作用,是药剂工作者从事临床药学应探讨的问题之一。据文献统计,在有关医院司药系统发生的医疗事故中,以服药时间的差错为最常见,约占16～18%。因此,时间用药已日益引起人们的注意。人和动物的许多生理功能和病理变化均呈现昼夜节律性,机体对药物的反应也因时而异,药物的吸收、分布、作用,代谢和排泄的速率都显示昼夜节律,由此提示一天中服药时 At present, many medical units are still in the medication 3 to 4 times a day, each time a piece or a grid of traditional means of administration. Study time medication, to give full play to the efficacy of the drug to reduce the number of medication, reduce toxicity, so that the best dose of drugs and the best time to play a better role in pharmacy workers engaged in clinical pharmacy should be one of the issues to be explored. According to the statistics of the literature, in the medical accidents that occurred in the hospital’s departmental medicine system, taking the time taken for medication was the most common, accounting for 16-18%. Therefore, time medication has drawn increasing attention. Circadian rhythms are present in many physiological functions and pathological changes in humans and animals. The response of the body to drugs varies from place to place. The absorption, distribution, action, metabolism, and excretion rates of the drugs show circadian rhythms, suggesting a daily dose of medication Time