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目的探讨在冷冻囊胚移植(FBT)周期中3种囊胚移植策略的临床结局。方法收集2013年1月-2016年10月在南京总医院行FBT的398个周期,分3组:1枚优质囊胚组(A组)、2枚优质囊胚组(B组)、1枚优质囊胚和1枚非优质囊胚组(C组),分析3组临床结局。结果 3组在种植率、临床妊娠率、流产率、异位妊娠率及活产率上差异均无统计学意义(P>0.05)。与A组相比,B、C两组在多胎率上均显著增加(P<0.01);与B组相比,C组多胎率显著下降(P<0.05);与A组相比,B组早产率显著增加(P<0.05)。结论单个优质囊胚移植可显著降低多胎率及早产率,为最优移植方案。与2枚优质囊胚策略相比,1枚优质囊胚和1枚非优质囊胚移植策略多胎率显著降低。
Objective To investigate the clinical outcomes of three kinds of blastocyst transplantation strategies in the frozen blastocyst transplantation (FBT) cycle. Methods The 398 cycles of FBT in Nanjing General Hospital from January 2013 to October 2016 were divided into three groups: one high quality blastocyst group (group A), two high quality blastocysts group (group B), one High-quality blastocysts and a non-high quality blastocysts group (C group), analysis of three groups of clinical outcomes. Results There was no significant difference in implantation rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate and live birth rate between the three groups (P> 0.05). Compared with group A, group B and C increased significantly at multiple birth rates (P <0.01). Compared with group B, the number of multiple births in group C decreased significantly (P <0.05). Compared with group A, group B Preterm birth rate increased significantly (P <0.05). Conclusion Single high quality blastocyst transplantation can significantly reduce the rate of multiple births and premature birth rate, which is the optimal transplantation plan. Compared with two high-quality blastocyst strategies, one high quality blastocyst and one non-high quality blastocyst transplantation strategy significantly reduced the rate of multiple births.