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单独给大鼠口服阈下剂量的阿魏酸钠(SF)或阿斯匹林(ASA)对胶原诱导的血小板聚集及对颈动脉壁PGI_2样物质的释放均无明显作用。两药并用后大鼠血小板聚集及血小板TXA:样物质的释放均显著地受到抑制,动脉壁PGI_2样物质的释放则无明显变化。说明SF与小剂量ASA联用可增强抗血小板作用。
Oral sublingual doses of sodium ferulate (SF) or aspirin (ASA) administered alone to rats did not have a significant effect on collagen-induced platelet aggregation and release of PGI-2-like substances in the carotid artery wall. After administration of both drugs and platelet aggregation in rat platelet and platelet TXA: the release of substance were significantly inhibited, PGI_2-like substance in the arterial wall release was no significant change. Description SF and low-dose combination of ASA can enhance anti-platelet effect.