中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)构建的复杂层面为中药复方研究,在坚持多成分同时测定的前提下,开展渗透性研究时,其首要任务是明确透过肠壁而被吸收的成分来源,即具体归属于中药复方中的哪味药材。该研究利用化学成分指纹图谱技术(chemical fingerprint),采用离体翻转肠囊实验技术对经典名方葛根芩连方中的肠渗透多成分进行直观来源归属,为下一步的肠渗透性定性及定量研究奠定基础。 The complex level of the biopharmaceutics classification system of Chinese materia medica (CMMBCS) is a traditional Chinese medicine compound study. The primary task of carrying out the permeability study while insisting on the simultaneous determination of multiple components is to clarify that through the intestine The source of the components that are absorbed by the wall, ie, which herbs are attributed to the compound of traditional Chinese medicine. In this study, chemical fingerprinting (chemical fingerprint) was used to visualize the intestine infiltration of multiple components in the classical puerarin-Gegen Qinlian prescription by using the technology of in vitro flip-enteral experiment. It is the next step of qualitative and quantitative determination of intestinal permeability Research laid the foundation.