论文部分内容阅读
目的观察高龄糖尿病合并慢性肾病应用前列地尔治疗的效果。方法选择2013年3月—2015年3月收治的高龄糖尿病合并慢性肾病患者80例,按随机数字法分为两组,对照组患者采取常规治疗,观察组在对照组的基础上,采取前列地尔注射液治疗,比较两组临床疗效。结果观察组与对照组总有效率分别为92.50%、77.50%,观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组治疗后ACR、SCr、BUN、TG水平优于治疗前,差异有统计学意义(均P<0.05)。观察组UAER水平优于治疗前,差异有统计学意义(P<0.05)。观察组UAER、ACR、SCr、BUN、TG优于对照组,差异有统计学意义(均P<0.05)。两组患者不良反应发生情况比较,差异无统计学意义(P>0.05)。结论前列地尔是一种治疗高龄糖尿病合并慢性肾脏疾病的有效药物,且安全性较高。
Objective To observe the effect of alprostadil treatment in elderly patients with chronic kidney disease. Methods Eighty elderly patients with chronic diabetic nephropathy who were admitted to our hospital from March 2013 to March 2015 were randomly divided into two groups according to random number method. The patients in the control group were treated routinely. On the basis of the control group, Seoul injection treatment, the clinical efficacy of two groups were compared. Results The total effective rates of the observation group and the control group were 92.50% and 77.50%, respectively. The total effective rate in the observation group was higher than that in the control group (P <0.05). The levels of ACR, SCr, BUN and TG in the two groups were better than those before treatment (all P <0.05). The level of UAER in observation group was better than that before treatment, the difference was statistically significant (P <0.05). The levels of UAER, ACR, SCr, BUN and TG in the observation group were better than those in the control group (all P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Alprostadil is an effective drug for the treatment of chronic kidney disease in elderly patients with diabetes and is more safe.