Aim:To evaluate the association between selected potential socio-demographic and behavioral risk factors and infer-tility in Nigerian men.Methods:There were two groups in this study.One group consisted of 150 men with provenmale infertility,and the other consisted of 150 fertile men with normal semen parameters.Both were matched for age,place of residence and key socio-demographic variables.They were compared for sexual history,past medical andsurgical history,past exposures to sexually transmitted infections and treatment,past and current use of drugs as wellas smoking and alcohol intake history.Results:Infertile men were significantly more likely than fertile men to reporthaving experienced penile discharge,painful micturition and genital ulcers,less likely to seek treatment for thesesymptoms and more likely to seek treatment with informal sector providers.Multivariate analysis showed that maleinfertility was significantly associated with bacteria in semen cultures,self-reporting of previous use of traditionalmedications and moderate to heavy alcohol intake,but not with smoking and occupational types.Conclusion:Infertility is associated with various proxies of sexually transmitted infections (STIs) and poor healthcare-seekingbehavior for STIs in Nigerian men.(Asian J Androl 2005 Dec;7:351-361) Aim: To evaluate the association between selected potential socio-demographic and behavioral risk factors and infer-tility in Nigerian men. Methods: There were two groups in this study. One group consisted of 150 men with provenmale infertility, and the other consisted of 150 fertile men with normal semen parameters.Both were matched for age, place of residence and key socio-demographic variables. They were compared for sexual history, past medical andsurgical history, past exposures to sexually transmitted infections and treatment, past and current use of drugs as wellas smoking and alcohol intake history. Results: Infertile men were significantly more likely than fertile men to reporthaving experienced penile discharge, painful micturition and genital ulcers, less likely to seek treatment for thesesymptoms and more likely to seek treatment with informal sector providers .Multivariate analysis showed that maleinfertility was significantly associated with bacteria in semen cultures, self-reporting of previous use of traditional medications and moderate to heavy alcohol intake, but not with smoking and occupational types. Conclusion: Infertility is associated with various proxies of sexually transmitted infections (STIs) and poor healthcare-seeking behavior for STIs in Nigerian men. (Asian J Androl 2005 Dec; 7: 351-361)