论文部分内容阅读
目的:探讨中西医结合治疗急性髓系白血病(AML)诱导缓解期疗效。方法:采用回顾性资料分析方法,对20例初治AML患者病例资料进行临床疗效总结和研究对比,并根据治疗中是否使用中药将患者分为中药+化疗组(简称治疗组)和单纯化疗组(简称对照组)。观察诱导缓解期白血病患者的临床治疗效果,主要从临床疗效(完全缓解率、有效率、中医证候改善情况)、支持疗法、化疗药物不良反应等方面进行观察对比,分析中药参与治疗后有无治疗优势。结果:(1)两组CR率及有效率分别为50%和60%,60%和70%,治疗组CR率及有效率均低于对照组,经统计学检验,两组数据无明显差异(P>0.05)。治疗组中医证候改善情况其症状量化积分明显减少,治疗前后积分比较存在统计学差异(P<0.05)。(2)化疗过程中两组患者红细胞输注均量治疗组明显少于对照组,经比较有统计学差异(P<0.05),治疗组的血小板输注均量及粒细胞集落刺激因子使用均量少于对照组,经检验两组数据无统计学差异(P>0.05)。3、化疗过程中出现不良反应比较,其中肝损害发生率两组分别为30%和80%,治疗组明显低于对照组,经统计学检验,两组数据有明显差异(P<0.05)。结论:(1)中西医结合治疗AML,中药在支持疗法中显示出一定优势,可以减少患者的输血用量;(2)中药在减轻化疗药物的不良反应方面初见端倪;(3)中药参与治疗在提高白血病CR率方面有无优势?本项研究尚不能确定。
Objective: To investigate the therapeutic effect of traditional Chinese medicine and western medicine on acute myeloid leukemia (AML) induced remission period. Methods: A retrospective data analysis method was used to summarize and compare the clinical data of 20 newly diagnosed AML patients. According to whether traditional Chinese medicine was used in the treatment, the patients were divided into traditional Chinese medicine plus chemotherapy group (referred to as treatment group) and chemotherapy alone group (Referred to as the control group). To observe the clinical effect of induction of leukemia in remission patients, mainly from the clinical efficacy (complete remission rate, effective rate, the improvement of traditional Chinese medicine syndrome), supportive therapy, adverse reactions of chemotherapy drug observation and comparison, analysis of Chinese medicine after treatment with or without Treatment advantage. Results: (1) The CR rate and effective rate were 50% and 60%, 60% and 70% respectively in both groups. The CR rate and effective rate in the treatment group were lower than those in the control group. There was no significant difference between the two groups (P> 0.05). The improvement of TCM syndromes in the treatment group showed a significant reduction of the quantified scores of the symptoms, and the scores of the scores before and after treatment showed significant difference (P <0.05). (2) During the course of chemotherapy, the average amount of red blood cells transfused in the two treatment groups was significantly less than that in the control group (P <0.05). The average amount of platelet transfusion and the use of granulocyte colony stimulating factor The amount of less than the control group, the test data showed no significant difference between the two groups (P> 0.05). Adverse reactions in the course of chemotherapy were compared. The incidence of liver damage was 30% and 80% respectively in the two groups. The treatment group was significantly lower than the control group. There was significant difference between the two groups (P <0.05). Conclusion: (1) Integrative Chinese and Western medicine treatment of AML, Chinese medicine in supportive therapy showed some advantages, can reduce the amount of blood transfusion in patients; (2) Chinese medicine in the mitigation of adverse effects of chemotherapy drugs initially; (3) Chinese medicine treatment Are there any advantages in improving the CR rate of leukemia? The study is still not clear.