慢性乙型肝炎病毒感染s5例,随机分无环鸟苷长程组22例,短程组11例和对照组22例。经一年随访观察,无环鸟苷治疗组见血清HBeAg、DNA-P和HBV-DNA有规律性阴转,短程组于12个月又有部分指标阳转,长程组阴转较多,其血清HBeAg、DNA-P和HBV-DNA阴转率与短程和对照组比较有显著性差异。一年结果四项病毒复制指标全部阴转例数与对照组有显著性差异,结果表明,无环鸟苷长疗程是有较好疗效。 Five cases of chronic hepatitis B virus infection were randomized to 22 cases of acyclovir long-term group, 11 cases of short-term group and 22 cases of control group. After one-year follow-up, there was a regular pattern of negative conversion of serum HBeAg, DNA-P and HBV-DNA in acyclovir treatment group, positive in some extent in short-term group at 12 months, Serum HBeAg, DNA-P and HBV-DNA negative rate and short-term and control groups were significantly different. The result of one year showed that all four cases of virus replication index had significant difference with the control group, and the results showed that acyclovir treatment had a long effect.