论文部分内容阅读
目的探讨在相近的原发性高血压(EH)发病的遗传背景下,环境因素对原发性高血压发生的影响。方法从57户高血压家系中,选取60个年龄相近、性别相同的同胞对,其中一人为原发性高血压患者,另一人为血压正常者,进行1∶1配对病例对照研究;应用多因素条件Logistic回归分析筛选原发性高血压的易患危险因素,数据分析采用SPSS 12.0统计软件。结果单因素分析结果显示,吸烟、饮酒、血糖、甘油三酯(TG)、胆固醇(CHOL)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血钾、血纳、血钙在对照组与病例组之间差异均无统计学意义(P>0.05),仅体质指数(BM I)在对照组与病例组之间差异有统计学意义(P<0.05);多因素条件Logistic回归分析结果显示,BM I可能是原发性高血压的易患危险因素(OR=29.330,95%CI=2.594~331.613)。结论在相近的遗传条件下,BM I可能是原发性高血压的易患危险因素。
Objective To explore the influence of environmental factors on the occurrence of essential hypertension in the genetic background of the similar essential hypertension (EH). Methods Fifty-six hypertensive pedigrees were selected from 60 pairs of siblings with similar age and sex. One of them was essential hypertension and the other was normotensive. A 1: 1 matched case-control study was performed. Logistic regression analysis of risk factors for screening essential hypertension, data analysis using SPSS 12.0 statistical software. Results The results of univariate analysis showed that smoking, drinking alcohol, blood glucose, triglyceride, CHOL, HDL, LDL, There was no significant difference between the control group and the case group (P> 0.05), only the BMI was significantly different between the control group and the case group (P <0.05); the multivariate Logistic regression The results showed that BM I may be a predisposing risk factor for essential hypertension (OR = 29.330, 95% CI = 2.594 ~ 331.613). Conclusion Under similar genetic conditions, BM I may be a predisposing risk factor for essential hypertension.