患者　女，１８岁。因原发性闭经及多饮、多尿、多食伴消瘦１月入院。患者系足月顺产第３胎，父母非近亲婚配。无糖尿病家族史。有一兄一姐均已婚并正常生育。查体：身高１５５ｃｍ，体重４５ｋｇ。智力正常，无听力障碍。无颈蹼及肘外翻，心、肺正常。无阴、腋毛，乳房未发育 Patient female, 18 years old. Due to primary menopause and polydipsia, polyuria, more food with weight loss January admission. Full-term third-trimester child birth, non-relatives of the marriage. Family history without diabetes. One brother and one sister are married and have regular births. Physical examination: height 155cm, weight 45kg. Normal intelligence, no hearing impairment. No neck webbed and elbow valgus, heart, lungs normal. No shade, armpit hair, undeveloped breasts