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目的:①观察中药更年妇康汤治疗美国妇女更年期综合征的临床疗效。②观察双吲哚甲烷提升尿液2/16a羟基雌酮比例的临床疗效。方法:将79例患者随机分为治疗组49例,其中经中医辨证肾虚肝旺型32例,肾阴阳俱虚型17例;对照组共35例,含肾虚肝旺型12例,肾阴阳俱虚型18例。治疗组口服中药更年妇宝丸,对照组口服洋草药黑升麻,西方牡荆和庭院鼠尾草方(简称麻荆尾方)。观察治疗组的临床疗效。另外,每位患者加服双吲哚甲脘,于服药前及90天后随机检查13例患者(肾虚肝旺型10例,肾阴阳俱虚型3例)尿液2/16a羟基雌酮代谢物的比例变化。结果:中医辨证肾虚肝旺型的治疗组和对照组的总有效率分别为93.7%和55.0%;肾阴阳俱虚型的治疗组和对照组总有效率分别为94.2%和50.0%,差异均有统计学意义(P<0.049与P<0.005)。这显示中药更年妇宝丸的疗效优于对照组。检查13例患者尿液2/16a羟基雌酮比例显示,用药前平均为1.75,用药后为1.81,此差异具统计学意义(P<0.025)。结论:中药更年妇康汤治疗更年期综合征中肾虚肝旺型和肾阴阳俱虚型有较好的临床疗效。双吲哚甲烷有优化雌激素代谢的作用。
PURPOSE: To observe the clinical efficacy of Chinese herbal medicine for senile menopause in senile men’s syndrome. ② To observe the clinical efficacy of bisindole methane to enhance urinary 2 / 16a hydroxy estrone ratio. Methods: 79 patients were randomly divided into treatment group (49 cases), of which 32 cases were treated by syndrome differentiation of kidney deficiency and liver deficiency type, 17 cases were yin and yang deficiency of kidney type, 35 cases in control group 18 cases of deficiency. The treatment group oral Chinese medicine more elderly women pills, the control group oral herbs black cohosh, Western Vitex and garden sage side (referred to as Ma Jingwei side). Observed the clinical efficacy of the treatment group. In addition, each patient plus double-indole methyl formazan, before taking medication and 90 days after random inspection of 13 patients (kidney Wang Wang type in 10 cases, yin and yang deficiency of the kidney in 3 cases) urine 2 / 16a hydroxy estrone metabolites The proportion of changes. Results: The total effective rate of treatment group and control group of TCM syndrome differentiation kidney deficiency type was 93.7% and 55.0%, respectively. The total effective rates of treatment group and control group were 94.2% and 50.0% respectively There was statistical significance (P <0.049 and P <0.005). This shows that the more effective drug pills than the control group. Examination of 13 patients urinary 2 / 16a hydroxy estrone ratio showed an average of 1.75 before treatment, after treatment was 1.81, this difference was statistically significant (P <0.025). Conclusion: The Chinese medicine more nongfu decoction treatment of climacteric syndrome kidney deficiency type and kidney yin and yang deficiency have better clinical efficacy. Bisindole methane has the effect of optimizing estrogen metabolism.