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萎缩性胃炎的发病机理和病因包括免疫学方面及非免疫学的病因。一、体液免疫:患者血中存在胃自家抗体,一种是直接对抗壁细胞微粒体部分的壁细胞抗体,另一种是对壁细胞中内因子的内因子抗体。二、细胞免疫的超敏反应:从胃粘膜组织可见到参与迟发性超敏反应的淋巴细胞、浆细胞弥漫浸润胃粘膜,提示了细胞免疫机制的存在。通过动物实验及体外淋巴细胞转化试验与细胞移动抑制试验均证明了细胞过敏损害可能导致萎缩性胃炎。三、非免疫学病因:(一)慢性酒精中毒,酒精引起胃炎的严重程度直接与饮用烈酒的时间长短
The pathogenesis and causes of atrophic gastritis include both immunological and non-immunological causes. First, humoral immunity: There are stomach self-antibodies in the patient’s blood, one is a parietal cell antibody that directly opposes the microsome part of the parietal cells, and the other is an intrinsic factor antibody to the intrinsic factor in parietal cells. Second, the hypersensitivity of cellular immunity: visible from the gastric mucosa to participate in delayed hypersensitivity of lymphocytes, plasma cells diffuse infiltration of gastric mucosa, suggesting the existence of cellular immune mechanisms. Through animal experiments and in vitro lymphocyte transformation assays and cell migration inhibition assays, it was demonstrated that cellular allergic lesions may lead to atrophic gastritis. Third, non-immunological etiology: (a) chronic alcoholism, alcohol-induced gastritis severity directly with the length of drinking spirits